Annatto Tocotrienol Modifies Metabolism for Favorable Oxidative Inflammatory Responses

Hadley, Massachusetts (January 4, 2022) ‘Unambiguous nutritional benefits’: Annatto tocotrienol positively affects multiple biochemicals in the human body, says study

“Annatto tocotrienol resets the body’s nutritional metabolism and redirects endogenous nutrient biochemistry. This first-of-a-kind study shows unambiguous nutritional benefits of tocotrienol to everyone, especially for adults and postmenopausal women.”​  -Dr Tan.

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Study details

The new study included 89 postmenopausal women with confirmed osteopenia were randomly assigned to one of three groups: Placebo, 300 mg per day of DeltaGold® or 600 mg per day of DeltaGold® for 12 weeks. All of the groups also received daily calcium and vitamin D supplements. For the metabolomic analysis, 20 women from the placebo and 600 mg groups were randomly selected.

The results showed that levels of delta-tocotrienol and its metabolite were higher after 12 weeks of supplementation. The tocotrienol was incorporated into tissue cell membranes to improve phospholipids in favor of long-chain fatty acids.

Metabolomic analysis indicated that tocotrienol supplementation led to many biochemical changes, including conserving methionine to increase cysteine and glutathione, and decreasing homocysteine; conserving tyrosine to potentiate protein synthesis; and modifying microbiome-friendly and detox-friendly metabolites.

“Differences in compounds associated with bone degradation/collagen turnover indicate […] that TT affects bone metabolism and collagen synthesis/degradation,” ​wrote the researchers.

“As the members of the vitamin E family gaining more recent interests, tocotrienols have demonstrated broad biological effects on oxidative stress, inflammation, cell proliferation, adipogenesis, osteoclastogenesis, and osteoblastogenesis, and lipid metabolism,” ​they added.

“Our findings provide evidence to pursue future studies that would afford a mechanistic understanding of the nutritional values and health benefits of tocotrienols on bone remodeling and osteoblast functions.”

Source: Frontiers in Nutrition
December 2021, doi: 10.3389/fnut.2021.766711
“Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial”
Authors: C-L. Shen et al.

About American River Nutrition, LLC

American River Nutrition (ARN) was founded in 1998 by Dr. Barrie Tan and is located in Hadley, MA.  ARN’s mission focuses on the scientific advancement of the health benefits of Bixa orellana, a tropically grown plant commonly known as annatto. ARN manufactures its products in Massachusetts at its state-of-art, GMP compliant, 24,000 square foot facility using a range of proprietary processes and technologies. To learn more, visit