Study on DeltaGold Annatto Tocotrienols’ Effect on Fatty Liver Disease (24 week study)
24-week randomized, double-blind, placebo-controlled trial of 71 NAFLD patients given 300mg of DeltaGold annatto tocotrienol twice daily in combination with a lifestyle modification of regular physical activity and reduced fat and carb diet. Patients who were administered annatto tocotrienols saw reduced biomarkers related to NAFLD, and additionally, they experienced significant improvements in fatty liver index and HOMA-IR scores compared to placebo. Tocotrienols also appeared to decrease the degree of hepatic steatosis in NAFLD patients.
Pervez, Muhammad Amjad, et al. “Delta-Tocotrienol Supplementation Improves Biochemical Markers of Hepatocellular Injury and Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled Trial.” Complementary Therapies in Medicine, vol. 52, 2020, p. 102494., doi:10.1016/j.ctim.2020.102494. Read More
Study on DeltaGold Annatto Tocotrienol’s Effect on Gut Microbiota in Mice
14-week study in mice modeled after type 2 diabetes (T2DM) receiving either a low-fat diet, a high-fat diet, or a high-fat diet supplemented with annatto tocotrienols at 800 mg/kg, which is equivalent to the human dosage of about 320 mg daily. Annatto tocotrienol supplementation resulted in alteration to the gut microbiome and positive metabolic outcomes in mice that were exposed to a high-fat diet. Supplementation improved parameters associated with metabolic disorders.
Chung, Eunhee, et al. “Metabolic Benefits of Annatto-Extracted Tocotrienol on Glucose Homeostasis, Inflammation, and Gut Microbiome.” Nutrition Research, vol. 77, 2020, pp. 97–107., doi:10.1016/j.nutres.2020.04.001 Read More
Study on DeltaGold Annatto Tocotrienol’s Effect on Advanced-Stage Ovarian Cancer
Open label study of 23 advanced-stage ovarian cancer patients taking 300mg of tocopherol-free tocotrienols (DeltaGold), three times per day in combination with 10mg/kg of Avastin taken intravenously every three weeks. Trial resulted in increased survival rates (both progression-free and overall) of almost double.
  Thomsen CB, Andersen RF, Steffensen KD, Adimi P, Jakobsen A. Delta tocotrienol in recurrent ovarian cancer. A phase II trial. Pharmacological research. 2019;141:392-6. Epub 2019/01/15 Read More
Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Fatty Liver Disease (12 week study)
Randomized, double-blind, placebo-controlled study of 71 subjects over 12 weeks examining the impact of tocotrienols on fatty liver disease in dosages of 600mg/d. Results showed DeltaGold decreased biomarkers associated with fatty liver.

Pervez MA, Khan DA, Ijaz A, Khan S. Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2018;29(2):170-6. Epub 2018/05/12 Read More

Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Osteopenia in Post-Menopausal Women
Randomized double-blind placebo-controlled study of 89 subjects examining the impact of tocotrienols on bone health in dosages of 300 and 600 mg/day of tocopherol-free tocotrienol from annatto (DeltaGold). Supplementation with tocotrienol decreased bone resorption and improved bone turnover rate in postmenopausal women.

Shen CL, Yang S, Tomison MD, Romero AW, Felton CK, Mo H. Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial. Osteoporos Int. 2018. Epub 2018/01/14.  Read More

Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Lipid Parameters
Open label study examining various dosages of tocopherol-free tocotrienol from annatto (DeltaGold) indicated the optimum dose to lower total cholesterol, LDL, triglycerides and cytokines associated with cardiovascular disease to be 250mg/day.

Qureshi AA et al. Dose-dependent modulation of lipid parameters, cytokines and RNA by δ-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet British Journal of Medicine & Medical Research 6(4): 351-366, 2015, Article no. BJMMR.2015.211  Read More

Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Inflammatory Markers
Open label study examining various dosages of tocopherol-free tocotrienol from annatto (DeltaGold) indicated the optimum dose to lower inflammation markers to be 250mg/day.

Qureshi AA et al. Impact of δ-tocotrienol on inflammatory biomarkers and oxidative stress in hypercholesterolemic subjects. Clinical & Experimental Cardiology 2015 vol. 6, Issue 4  Read More

Anti-Inflammatory Formulation Clinical Studies
These clinical studies show that delta-tocotrienol in combination with antioxidant polyphenols curb inflammation and manage dyslipidemia. One of the placebo-controlled studies was conducted in two groups of elderly subjects, one with normal and the other with elevated lipid levels. The product formulation was composed of delta-tocotrienol from annatto (as found in DeltaGold®), along with a B-vitamin (niacin) and polyphenols. In both groups, supplementation led to a significant drop in C-reactive protein (a predictor for chronic inflammation) and γ-glutamyl-transferase (a predictor for non-fatal myocardial infarction and fatal coronary heart disease), while increasing total antioxidant status, a measure of the body’s capacity to counteract reactive oxygen species. In the hypercholesterolemic group, LDL cholesterol (20-28%) and triglycerides (11-18%) also dropped. C-reactive protein dropped in healthy elderly (21-29%) as well as lipidemic elderly (31-48%), as did γ-glutamyl-transferase (14-20%). Notably, there were no adverse effects associated with the 6-week supplementation period.

Qureshi AA et al. Nutritional supplement-5 with a combination of proteasome inhibitors (resveratrol, quercetin, δ-tocotrienol) modulate age-associated biomarkers and cardiovascular lipid parameters in human subjects Clinical & Experimental Cardiology 2013 col. 4, issue 3  Read More

Qureshi AA, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N (2012) Suppression of nitric oxide Production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. J Clin Exp Cardiolog S5:008. doi:10.4172/2155-9880.S5-008  Read More 

An open-label randomized trial involving DeltaGold (125, 250, 500, 750, and 1,000 mg/d dosage groups) confirmed the bioavailability of tocopherol-free annatto tocotrienol. Delta- and gamma-tocotrienols are readily bioavailable if taken with a meal.

Qureshi AA, Khan DA, Saleem S, Silswal N, Trias AM, et al. (2015) Pharmacokinetics and bioavailability of annatto δ-tocotrienol in healthy fed subjects. J Clin Exp Cardiolog 6: 411. doi:10.4172/2155-9880.1000411  Read More

Omega-3 Protection (Antioxidant)
  200-500ppm tocotrienol from DeltaGold offers superior antioxidant protection of fish oil versus tocopherol-tocotrienol mixtures, or alpha-tocopherol.

Zou Z, Akoh C Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion Food Chemistry 168 (2015) 504–511  Read More