Annatto-Based Tocotrienols May Help Those with Prediabetes

Hadley, Massachusetts (February 15, 2022) Delta-tocotrienol from annatto may help improve glycemic control in patients with prediabetes, according to a trial published in the Journal of Pakistan Medical Association.

“For the first time, DeltaGold® tocotrienol was shown to improve primary and secondary outcomes in confirmed prediabetic subjects unambiguously.” -Dr. Tan

The 12-week randomized, double-blind, placebo-controlled trial studied 77 prediabetes patients, who received either a placebo or 300mg/day of DeltaGold®, an annatto-derived tocotrienol ingredient by American River Nutrition. All patients were advised to take up regular physical activity.

The trial found that HbA1c—a long-term stable measure of blood sugar control—was reduced from 6.04% to 5.77% in the test group, further away from the 7% threshold at which prediabetes can convert to type 2 diabetes. The placebo group not only didn’t see a decrease, but HbA1c actually increased, from 5.99 to 6.04%. The test group also saw reduced insulin and reduced insulin resistance, whereas the placebo group saw no change in these biomarkers.

A press release from American River Nutrition explains that prediabetes is a state of hyperglycemia, defined by the American Diabetes Association as having fasting glucose levels of 100.8-124.2mg/dl and glucose tolerance of 140.4-198mg/dl following ingestion of oral glucose. HbA1c levels for this condition are in the range of 5.7-6.4%. According to the CDC, prediabetes affected more than 1 in 3 U.S. adults in 2019. The yearly conversion rate from prediabetes to type 2 diabetes mellitus is 5-10%, but the conversion can be prevented with diet- and exercised-based interventions.

In the press release, Dr. Barrie Tan, President of American River Nutrition said that “studies into metabolic protection consistently underscored delta- and gamma-tocotrienol forms of vitamin E as the most potent for this application, with absence of alpha-tocopherol being key.” Recalling other recently published clinical trials studying annatto-derived tocotrienols in an array of metabolic disorders, Tan observed that “this prediabetes trial compliments two type 2 diabetes mellitus studies published in 2021, with DeltaGold®—containing 90% delta- and 10% gamma-tocotrienol—correcting metabolic disturbances brought on by prediabetes and diabetes alike.”

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Source: Journal of Pakistan Medical Association​
January 2022, doi: ​
“Effects of delta-tocotrienol supplementation on glycaemic control in individuals with prediabetes: A randomized controlled study
Authors: F. Suleman, et al.

About American River Nutrition, LLC

American River Nutrition (ARN) was founded in 1998 by Dr. Barrie Tan and is located in Hadley, MA.  ARN’s mission focuses on the scientific advancement of the health benefits of Bixa orellana, a tropically grown plant commonly known as annatto. ARN manufactures its products in Massachusetts at its state-of-art, GMP compliant, 24,000 square foot facility using a range of proprietary processes and technologies. To learn more, visit