STUDIES RELATED TO DELTAGOLD®

  1. Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Lipid Parameters
    Open label study examining various dosages of tocopherol-free tocotrienol from annatto (DeltaGold) indicated the optimum dose to lower total cholesterol, LDL, triglycerides and cytokines associated with cardiovascular disease to be 250mg/day.Qureshi AA et al.

    Dose-dependent modulation of lipid parameters, cytokines and RNA by δ-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet British Journal of Medicine & Medical Research 6(4): 351-366, 2015, Article no. BJMMR.2015.211

  2. B. Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Inflammatory MarkersOpen label study examining various dosages of tocopherol-free tocotrienol from annatto (DeltaGold) indicated the optimum dose to lower inflammation markers to be 250mg/day.Qureshi AA et al. Impact of δ-tocotrienol on inflammatory biomarkers and oxidative stress in hypercholesterolemic subjects. Clinical & Experimental Cardiology 2015 vol. 6, Issue 4
  3. C. Design of Clinical Study on DeltaGold Annatto Tocotrienol’s Effect on Bone Markers (study results to be published fall 2017). Double-blind placebo-controlled study of 89 subjects examining the impact of tocotrienols on bone health in dosages of 300 and 600 mg/day of tocopherol-free tocotrienol from annatto (DeltaGold).Shen C-L, Mo H, Yang S, et al. Safety and efficacy of tocotrienol supplementation for bone health in postmenopausal women: protocol for a dose– response double-blinded placebo-controlled randomised trial. BMJ Open 2016;6:e012572.doi:10.1136/bmjopen-2016-012572
  4. D. Anti-Inflammatory Formulation Clinical StudiesThese clinical studies show that delta-tocotrienol in combination with antioxidant polyphenols curb inflammation and manage dyslipidemia. One of the placebo-controlled studies was conducted in two groups of elderly subjects, one with normal and the other with elevated lipid levels. The product formulation was composed of delta-tocotrienol from annatto (as found in DeltaGold®), along with a B-vitamin (niacin) and polyphenols. In both groups, supplementation led to a significant drop in C-reactive protein (a predictor for chronic inflammation) and γ-glutamyl-transferase (a predictor for non-fatal myocardial infarction and fatal coronary heart disease), while increasing total antioxidant status, a measure of the body’s capacity to counteract reactive oxygen species. In the hypercholesterolemic group, LDL cholesterol (20-28%) and triglycerides (11-18%) also dropped. C-reactive protein dropped in healthy elderly (21-29%) as well as lipidemic elderly (31-48%), as did γ-glutamyl-transferase (14-20%). Notably, there were no adverse effects associated with the 6-week supplementation period.Qureshi AA et al. Nutritional supplement-5 with a combination of proteasome inhibitors (resveratrol, quercetin, δ-tocotrienol) modulate age-associated biomarkers and cardiovascular lipid parameters in human subjects Clinical & Experimental Cardiology 2013 col. 4, issue 3

    Qureshi AA, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N (2012) Suppression of nitric oxide Production and cardiovascular risk factors in healthy seniors and hypercholesterolemic subjects by a combination of polyphenols and vitamins. J Clin Exp Cardiolog S5:008. doi:10.4172/2155-9880.S5-008

  5. E. PharmacokineticsAn open-label randomized trial involving DeltaGold (125, 250, 500, 750, and 1,000 mg/d dosage groups) confirmed the bioavailability of tocopherol-free annatto tocotrienol. Delta- and gamma-tocotrienols are readily bioavailable if taken with a meal.Qureshi AA, Khan DA, Saleem S, Silswal N, Trias AM, et al. (2015) Pharmacokinetics and bioavailability of annatto δ-tocotrienol in healthy fed subjects. J Clin Exp Cardiolog 6: 411. doi:10.4172/2155-9880.1000411

    Qureshi AA, Khan DA, Silswal N, Saleem S, Qureshi N (2016) Evaluation of pharmacokinetics, and bioavailability of higher doses of tocotrienols in healthy fed humans. J Clin Exp Cardiolog 7: 434. doi:10.4172/2155-9880.1000434

  6. F. Omega-3 Protection (Antioxidant)200-500ppm tocotrienol from DeltaGold offers superior antioxidant protection of fish oil versus tocopherol-tocotrienol mixtures, or alpha-tocopherol.Zou Z, Akoh C Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion Food Chemistry 168 (2015) 504–511